The Synthesis of (–)-Spiroleucettadine

Richard A. Lamb; Guillaume Lessene; Bill C. Hawkins

doi:10.1055/s-0036-1591776

Synlett, Table of Contents

Synlett 2018; 29(09): 1125-1130
DOI: 10.1055/s-0036-1591776

synpacts

The Synthesis of (–)-Spiroleucettadine

Authors

Richard A. Lamb

^aDepartment of Chemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand Email: bhawkins@chemistry.otago.ac.nz
Guillaume Lessene*

^bThe Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia and Department of Medical Biology and Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria 3050, Australia Email: glessene@wehi.edu.au
Bill C. Hawkins *

^aDepartment of Chemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand Email: bhawkins@chemistry.otago.ac.nz

Abstract

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Abstract

The interesting history of (–)-spiroleucettadine, a marine natural product, is discussed along with some of our original unsuccessful synthetic strategies. Finally, we briefly discuss our reported enantiospecific synthesis of spiroleucettadine, and how we plan to use this as a platform for further studies around this interesting class of molecules.

Key words

total synthesis - marine natural products - oxidation - stereoselective synthesis - spiro compounds - spiroleucettadine

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References

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